Like the Father/Son/Holy Spirit, man is a triune being.  He is spirit; which is God conscience, soul, which is self conscience, and body which is world conscience.  When the Bible refers to your 'mind' it is talking about your soul, not the physical organ, the brain.  Your mind/soul is your memory, your emotions, your imagination all of which God wants us to have focused on Him (Matthew 22:37 / Deuteronomy 6:5).  Having your mind/soul fixed on God is important because it is what will govern your actions.  As we practice fixing our mind/soul on Him through meditation of His Word and being in His presence, His very presence will increase.

When Adam and Eve fell, the spirit man, which had been illuminated from heaven, died.  The spirit of a man that has not been born again has no capacity to appreciate the things of God.  Being born again brings back the connection to God through the Spirit. Some come to God temporarily out of a guilty conscience but do not fully give their life over to God and their spirit man remains dead, because they have not been born again.

Scriptures used in this message:

Thessalonians 5:23
Hebrews 4:12
Matthew 1:23
Matthew: 22:37
Psalms: 139
Matthew 28:20
Hebrews 13:5